The doors swung open at the stroke of midnight and the first of thousands of customers poured in all eager to be part of history.

At 12.01am Saturday, Nevada became the fifth state in the US to make selling recreational marijuana legal and fans of the drug came out in force.

Party town Las Vegas will be the biggest winner from the new legislation with a huge tax windfall of up to $60million predicted for the first two years.

Millions of tourists visiting Sin City are expected to make nearly two of every three purchases from marijuana retailers.

Some in the industry have said Vegas which attracts more than 42 million tourists annually will become the ‘mecca for marijuana’ overtakingthe likes of Amsterdam in Holland as the world capital of cannabis.

More than 500 people lined up outside the Euphoria Wellness dispensary in Enterprise, on the outskirts of Las Vegas, and cheers erupted as the doors opened.